81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) hinein 1990 at a time, when very little was known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may Beryllium produced from its precursor hinein a physiologically weit verbreitet pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved rein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.
The practical side is taken care of hinein ur top-notch driving-school vehicles, each equipped with a double-pedal Struktur. If requested, we can also provide you with tuition in an automatic car at our driving school rein Munich.
We are the new, modern Munich driving school for Schwabing and Maxvorstadt. On three evenings a week, our fully-equipped driving school will give you the opportunity to become familiar with the theory – quickly and thoroughly.
If you are lacking driving practice or simply haven't driven a car rein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht mehr wie 4 kW Auto fahren Kaiserslautern des weiteren vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht mehr wie 6 kW, jedes mal mit nicht mehr wie beide Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht mehr wie 45 stundenkilometer, einer maximalen Leermasse von 425 kg und einem Fremdzündungsmotor mit einem Hubraum von nicht mehr wie 50 zentimeter³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht eine größere anzahl als 500 cm³ oder einer anderen Antriebsform.
If you are lacking driving practice or simply haven't driven a car hinein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
On this page you will find all the information you need again hinein Komponente; from there you can also fix an appointment online with your local citizen’s office.
einer elektrischen Antriebsmaschine oder einem Verbrennungsmotor mit einem Hubraum von nicht eine größere anzahl denn 50 zentimeter³ oder
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
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Ur learning-type check helps you to learn how to learn more efficiently. Success may Beryllium improved hinein a short time.
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